Product Description: UNC2250 is a potent and selective Mer inhibitor with an IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3.
Applications: Cancer-Kinase/protease
Formula: C24H36N6O2
References: [1]Zhang, W., et al., Pseudo-cyclization through intramolecular hydrogen bond enables discovery of pyridine substituted pyrimidines as new Mer kinase inhibitors. J Med Chem, 2013. 56(23): p. 9683-92./[2]Xiaodong Wang, et al. Pyrimidine compounds for the treatment of cancer.WO2013177168A1.
CAS Number: 1493694-70-4
Molecular Weight: 440.58
Compound Purity: 99.92
Research Area: Cancer
Solubility: 0.1 M HCL : 12.5 mg/mL (ultrasonic;adjust pH to 3 with HCl)/DMSO : ≥ 10 mg/mL
Target: TAM Receptor