UNC2881, CAS 1493764-08-1

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-[[4-(1H-imidazol-1-yl)phenyl]methyl]-5-pyrimidinecarboxamide

Purity: ≥98%

Formula Markup: C25H33N7O2

Formula Weight: 463.5755

CAS Number: 1493764-08-1

Notes: UNC2881 is an inhibitor of Mer (IC50 = 4.3 nM), a member of the TAM family of receptor tyrosine kinases.{45606} It is selective for Mer over the remaining TAM family members Axl and TYRO3 (IC50s = 360 and 250 nM, respectively). UNC2881 inhibits phosphorylation of Mer in 697 B-ALL acute lymphoblastic leukemia cells (IC50 = 21.9 nM). It inhibits platelet aggregation and ATP release induced by type I equine fibrillar collagen in isolated human platelet-rich plasma when used at a concentration of 3 μM.

• Artikelnummer: CAY29012-10
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 29012-10
• Verpackungseinheit: 10 mg
• Mengeneinheit: STK