Product Description: UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM. UNC3230 also inhibits PIP4K2C and does not inhibit any of the other lipid kinases that regulate phosphoinositide levels. UNC3230 has antinociceptive and anticancer effects[1].
Applications: COVID-19-immunoregulation
Formula: C17H20N4O2S
References: [1]Wright BD, et al. The lipid kinase PIP5K1C regulates pain signaling and sensitization. Neuron. 2014 May 21;82(4):836-47./[2]Peng W, et al. Type Iγ phosphatidylinositol phosphate kinase promotes tumor growth by facilitating Warburg effect in colorectal cancer. EBioMedicine. 2019 Jun;44:375-386./[3]Wright BD, et al. Development of a High-Throughput Screening Assay to Identify Inhibitors of the Lipid Kinase PIP5K1C. J Biomol Screen. 2015 Jun;20(5):655-62.
CAS Number: 1031602-63-7
Molecular Weight: 344.43
Compound Purity: 99.78
Research Area: Cancer; Inflammation/Immunology
Solubility: DMSO : 125 mg/mL (ultrasonic)
Target: Others
Deutsch
English
