Uprosertib, CAS 1047634-65-0

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-[(1S)-2-amino-1-[(3,4-difluorophenyl)methyl]ethyl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-furancarboxamide

Purity: ≥98%

Formula Markup: C18H16Cl2F2N4O2

Formula Weight: 429.2

CAS Number: 1047634-65-0

Notes: Uprosertib is a selective, orally bioavailable inhibitor of Akt (IC50s = 180, 328, and 38 nM for Akt1, Akt2, and Akt3, respectively).{32165} Uprosertib preferentially inhibits the proliferation of human cancer cell lines with Akt pathway activation via PI3K/PTEN mutation or loss.{30969} It can cause cell cycle arrest and consequent tumor growth inhibition in mice bearing either BT474 breast tumor or SKOV3 ovarian tumor xenografts.{30969}

• Artikelnummer: CAY19904-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 19904-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK