Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 7,9-dihydro-1H-purine-2,6,8(3H)-trione, monosodium salt
Formula Markup: C5H3N4O3 / Na
Formula Weight: 190.1
CAS Number: 1198-77-2
Notes: Uric acid is a ubiquitous end product of purine metabolism in humans that is mainly excreted in urine, whereas in other mammals it is further metabolized to allantoin by uricase.{26400} The final two steps in its production are catalyzed by xanthine oxidase, which generates superoxide.{26402} Uric acid acts as a potent peroxynitrite scavenger and antioxidant.{26400,26402,6143} However, high levels of serum uric acid (>120 µg/ml), termed hyperuricemia, are associated with gout, kidney stones, metabolic syndrome, hypertension, renal disease, and cardiovascular disease.{26400,18377,18381,18380,18379} Uric acid in the form of monosodium urate crystals has been proposed to trigger interleukin-1β-mediated inflammation by activating the NOD-like receptor protein 3 inflammasome.{26401}
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