Product Description: UT-34 is a potent, selective, orally bioactive second-generation pan-androgen receptor (AR) antagonist and degrader, with IC50 values of 211.7 nM, 262.4 nM, and 215.7 nM for wild-type AR, F876L-AR, and W741L-AR, respectively. UT-34 binds to the ligand-binding domain (LBD) and functional 1 (AF-1) domain of AR and requires the ubiquitin-proteasome pathway for AR degradation. UT-34 has anti-prostate cancer effects.
Applications: Metabolism-protein/nucleotide metabolism
Formula: C15H12F4N4O2
References: [1]Ponnusamy S, et al. Orally Bioavailable Androgen Receptor Degrader, Potential Next-Generation Therapeutic for Enzalutamide-Resistant Prostate Cancer. Clin Cancer Res. 2019 Nov 15;25(22):6764-6780./[2]Stone L. UT-34: a promising new AR degrader. Nat Rev Urol. 2019 Nov;16(11):640.
CAS Number: 2168525-92-4
Molecular Weight: 356.27
Compound Purity: 98.61
Research Area: Cancer; Endocrinology
Solubility: DMSO : 250 mg/mL (ultrasonic)
Target: Estrogen Receptor/ERR
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