Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: (2S)-2-amino-4-[bis[[2-[(3-methylphenyl)methoxy]phenyl]methyl]amino]-butanoic acid
Purity: ≥95%
Formula Markup: C34H38N2O4
Formula Weight: 538.6766
CAS Number: 1855871-76-9
Notes: V-9302 is an inhibitor of amino acid transporter 2 (ASCT2).{56045} It inhibits glutamine uptake with IC50 values of 9 and 9.6 µM for the rat and human transporters, respectively. V-9302 also inhibits glutamine uptake in HEK293 cells and reduces cell viability of a variety of cancer cell lines, including HCT116, HT-29, COLO 205, and RKO cells (EC50s = 8.9, 9.4, 14.5, and 8.3 µM, respectively).{56046} It reduces glutamine uptake into tumor tissue and prevents tumor growth in HCT116 and HT-29 mouse xenograft models expressing K-RasG13D and BRAFV600E mutations, respectively, when administered at a dose of 75 mg/kg per day for 21 days.
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