Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-(ethoxy-d5)-6-[2-[1-(6-methyl-3-pyridazinyl)-4-piperidinyl]ethoxy]-1,2-benzisoxazole
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C21H21D5N4O3
Formula Weight: 387.4866
CAS Number: 2738376-73-1
Notes: Vapendavir-d5 is intended for use as an internal standard for the quantification of vapendavir (Item No. 30546) by GC- or LC-MS. Vapendavir is a capsid-binding antiviral agent.{52755,52756} It binds to a pocket in the human rhinovirus (HRV) strain HRV2 VP1 capsid protein and inhibits the cytopathic effects of HRV2 and HRV14 in HeLa Ohio cells (EC50s = 1 and 5 ng/ml, respectively), as well as in a panel of 39 HRV clinical isolates (median EC50 = 7.3 ng/ml).{52755} Vapendavir inhibits replication in a panel of 21 enterovirus 71 (EV71) isolates with an average EC50 value of 0.7 μM.{52756}
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