Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-(2-ethoxy-5-((4-(ethyl-d5)piperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one
Purity: ≥99% deuterated forms (d1-d5)
Formula Markup: C23H27D5N6O4S
Formula Weight: 493.63452
CAS Number: 1189685-70-8
Notes: Vardenafil-d5 is intended for use as an internal standard for the quantification of vardenafil (Item No. 14930) by GC- or LC-MS. Vardenafil is a potent inhibitor of phosphodiesterase 5 (PDE5; IC50s = 0.2-1.2 nM) and PDE6 (IC50 = 2 nM).{24530,24529,24568} It is selective for PDE5 and PDE6 over PDE1 and PDE11 (IC50s = 230 and 130 nM, respectively). Vardenafil (4 mg/kg per day for three weeks) improves erectile function in a rat model of acute arteriogenic erectile dysfunction by increasing intracavernous pressure and mean arterial pressure, and this effect persists for at least two weeks following the end of treatment.{41771} Chronic vardenafil administration at a dose of 2 mg/kg for five weeks to subordinate mice reduces the latency to mount and increases the frequency of mounting behavior.{41772} Formulations containing vardenafil have been used in the treatment of erectile dysfunction.
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