Product Description: Verproside, a catalpol derivative iridoid glycoside isolated from the genus Pseudolysimachion, represses TNF-α -induced MUC5AC expression by inhibiting NF-κB activation via the IKK/IκB signaling cascade. Verproside has potent anti-inflammatory, antioxidant, antinociceptive and anti-asthmatic activities. Verproside has the potential for the study of chronic obstructive pulmonary disease (COPD)[1].
Formula: C22H26O13
References: [1]Lee SU, et al. Verproside inhibits TNF-α-induced MUC5AC expression through suppression of the TNF-α/NF-κB pathway in human airway epithelial cells. Cytokine. 2016 Jan;77:168-75./[2]Oh SR, et al. Suppressive effect of verproside isolated from <i>Pseudolysimachion</i> longifolium on airway inflammation in a mouse model of allergic asthma. Int Immunopharmacol. 2006 Jun;6(6):978-86. Epub 2006 Feb 10.
CAS Number: 50932-20-2
Molecular Weight: 498.43
Research Area: Infection; Inflammation/Immunology
Solubility: 10 mM in DMSO
Target: IKK;NF-κB;TNF Receptor
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