Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 2-[[(3-fluoro-3'-methoxy[1,1'-biphenyl]-4-yl)amino]carbonyl]-1-cyclopentene-1-carboxylic acid
Purity: ≥98%
Formula Markup: C20H18FNO4
Formula Weight: 355.4
CAS Number: 717824-30-1
Notes: Dihydroorotate dehydrogenase (DHODH) is involved in pyrimidine nucleoside biosynthesis. DHODH inhibitors have value in autoimmune diseases as well as cancer and certain infections.{31187} Vidofludimus is an immunosuppressive drug that inhibits DHODH (IC50s = 0.134, 1.29, and 10.6 µM for human, rat, and mouse isoforms, respectively).{31185,31186} Through this action, it inhibits the proliferation of T cells and B cells and the secretion of IL-17 (IC50s = 12.9, 3.7, and 6.0 µM, respectively, in human cells).{31185,31186} Oral administration of vidofludimus improves both chronic dextran sodium sulfate-induced and acute TNBS-induced colitis in mice.{31185}
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