Vigabatrin-13C-d2 (hydrochloride), CAS 2749628-08-6

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: 4-aminohex-5-enoic-6-13C-6,6-d2 acid, monohydrochloride

Purity: ≥99% deuterated forms (d1-d2)

Formula Markup: C5[13C]H9D2NO2 / HCl

Formula Weight: 168.6

CAS Number: 2749628-08-6

Notes: Vigabatrin-13C-d2 is intended for use as an internal standard for the quantification of vigabatrin (Item No. 9000976) by GC- or LC-MS. Vigabatrin is an irreversible GABA transaminase (GABA-T) inhibitor.{55297} It inhibits rat brain GABA-T when used at a concentration of 0.1 mM. Vigabatrin is selective for rat brain GABA-T over P. fluorescens GABA-T at 10 mM and is 100-fold selective over glutamic acid decarboxylase (GAD). Vigabatrin (1,500 mg/kg) decreases brain GABA-T activity without affecting GAD activity in mice.{55298} It reduces the incidence of myoclonus in a mouse model of audiogenic seizures.{55299} Vigabatrin also increases the electroconvulsive threshold in mouse model of maximal electroshock-induced seizures and reduces the number of clonic convulsions induced by pentylenetetrazol (PTZ; Item No. 18682) in mice.{55300} Formulations containing vigabatrin have been used in the treatment of seizures and infantile spasms.

• Artikelnummer: CAY26672-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26672-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung