Product Description: Vinpocetine (Ethyl apovincaminate) is a derivative of the alkaloid Vincamine that blocks voltage-gated Na+ channels. The IC50 value of Vinpocetine on direct IKK inhibition in the cell-free system is 17.17 μM. Vinpocetine is a phosphodiesterase (PDE) inhibitor and inhibits NF-κB-dependent inflammatory responses by directly targeting IκB kinase complex (IKK), and has been widely used for the treatment of cerebrovascular disorders[1][2][3].
Applications: COVID-19-immunoregulation
Formula: C22H26N2O2
References: [1]Kye-Im Jeon et al. Vinpocetine inhibits NF-κB-dependent inflammation via an IKK-dependent but PDE-independent mechanism PNAS May 25, 2010 vol. 107 no. 21 9795-9800/[2]Patyar S, et al. Role of vinpocetine in cerebrovascular diseases. Pharmacol Rep. 2011;63(3):618-28./[3]Alexandre E. Medina Vinpocetine as a potent antiinflammatory agent PNAS June 1, 2010, Vol. 107, No. 22 9921-9922.
CAS Number: 42971-09-5
Molecular Weight: 350.45
Compound Purity: 99.87
Research Area: Inflammation/Immunology; Neurological Disease; Cardiovascular Disease; Cancer
Solubility: DMSO : 6.25 mg/mL (ultrasonic)/Ethanol : 14.29 mg/mL (ultrasonic)
Target: IKK;Phosphodiesterase (PDE);Sodium Channel
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