VLX600, CAS 327031-55-0

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: 1-(2-pyridinyl)-ethanone, 2-(6-methyl-5H-1,2,4-triazino[5,6-b]indol-3-yl)hydrazone

Purity: ≥95%

Formula Markup: C17H15N7

Formula Weight: 317.4

CAS Number: 327031-55-0

Notes: VLX600 is a compound that shows selective cytotoxicity against quiescent cancer cells (IC50 = 1-10 µM) with selectivity for malignant cells.{28502} It induces necrosis in non-proliferating quiescent core cells in multicellular spheroids (MCs) formed from HCT116 colon cancer cells.{28502} VLX600 induces the expression of genes associated with hypoxia, glycolysis, and p53 signaling, stimulates autophagy, and triggers mitochondrial dysfunction in MCs.{28502} It displays antitumor activity against colon cancer xenografts with minimal systemic toxicity in mice.{28502}

• Artikelnummer: CAY17192-25
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 17192-25
• Verpackungseinheit: 25 mg
• Mengeneinheit: STK