Product Description: VPC-14449 is a potent and selective inhibitor of the DNA-binding domain of the androgen receptor (AR-DBD), with IC50 of 0.34 μM for full-length human AR. VPC-14449 reduces the ability of full-length AR as well as AR variants to interact with chromatin. VPC-14449 can be used for the research of prostate cancer[1][2].
Applications: Cancer-programmed cell death
Formula: C10H10Br2N4OS
References: [1]Dalal K, et, al. Selectively targeting the DNA-binding domain of the androgen receptor as a prospective therapy for prostate cancer. J Biol Chem. 2014 Sep 19;289(38):26417-26429./[2]Dalal K, et, al. Bypassing Drug Resistance Mechanisms of Prostate Cancer with Small Molecules that Target Androgen Receptor-Chromatin Interactions. Mol Cancer Ther. 2017 Oct;16(10):2281-2291.
CAS Number: 1621375-32-3
Molecular Weight: 394.09
Compound Purity: 99.71
Research Area: Cancer
Solubility: DMSO : 125 mg/mL (ultrasonic)
Target: Androgen Receptor
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