Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 7-chloro-4-[4-[(2,4-dinitrophenyl)sulfonyl]-1-piperazinyl]-quinoline
Purity: ≥98%
Formula Markup: C19H16ClN5O6S
Formula Weight: 477.9
CAS Number: 1624602-30-7
Notes: VR23 is a chloroquine (Item No. 14194) derivative that functions as a proteasome inhibitor (IC50s = 1 nM, 50-100 nM, and 3 µM for trypsin-like, chymotrypsin-like, and caspase-like proteasomes, respectively).{30904} It also deregulates the activity of cyclin E and other centrosomal proteins, resulting in the induction of multiple centrosome amplification, abnormal spindle formation, uneven cytokinesis, irreversible mitotic arrest, and eventually apoptosis that is specific to cancer cells.{30904} In combination with the chymotrypsin-like proteasome inhibitor bortezomib (Item No. 10008822), VR23 can produce a synergistic effect in killing multiple myeloma cells, including those that are resistant to bortezomib.{30904}
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