VU-29, CAS 890764-36-0

Product Description: VU-29 is a positive allosteric modulator of metabotropic glutamate 5 (mGlu5) receptor (EC50=9 nM and Ki=244 nM for rmGluR5). VU-29 is selective for mGluR5 relative to other mGluR subtypes (EC50: rmGluR1/rmGluR2=557 nM/1.5 μM; hmGluR4=154 nM)[1][2].

Applications: Neuroscience-Neurodegeneration

Formula: C22H16N4O3

References: [1]Ayala JE, et al. mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning. Neuropsychopharmacology. 2009;34(9):2057-2071./[2]Chen Y, et al. Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. Mol Pharmacol. 2007;71(5):1389-1398.

CAS Number: 890764-36-0

Molecular Weight: 384.39

Compound Purity: 99.63

Research Area: Neurological Disease

Solubility: DMSO : 50 mg/mL (ultrasonic)

Target: mGluR

• Artikelnummer: MEXHY-107508-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-107508-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK