Product Description: VU0366369 (ML137) is a selective positive allosteric modulator (PAM) for mAChR M1 with an EC50 of 830 nM. VU0366369 can be used in research about central nervous system diseases[1].
Formula: C19H14FN3O2
References: [1]Bridges TM, et al., Chemical lead optimization of a pan Gq mAChR M1, M3, M5 positive allosteric modulator (PAM) lead. Part II: development of a potent and highly selective M1 PAM. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1972-5.
CAS Number: 1222834-53-8
Molecular Weight: 335.33
Research Area: Neurological Disease
Target: Cholinesterase (ChE)