Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 7-bromo-2-(4-hydroxyphenyl)-5-benzoxazolol
Purity: ≥98%
Formula Markup: C13H8BrNO3
Formula Weight: 306.1
CAS Number: 440122-66-7
Notes: WAY-200070 is a potent and selective agonist of estrogen receptor β (ERβ; IC50s = 2 and 187 nM for human full-length ERβ and ERα, respectively).{39360} WAY-200070 (30 mg/kg, s.c. in mice) induces nuclear translocation of ERβ and increases c-fos activation and dopamine levels in the striatum four hours after administration.{39359} At the same dose, it decreases depressive-like behavior in the tail suspension test. It has anxiolytic effects in mice using the four-plate and stress-induced hyperthermia tests and in zebrafish larvae using a light-dark choice behavior test.{39359,39358} In addition, WAY-200070 improves glucose and insulin sensitivity in mouse models of diabetes.{39357}
Deutsch
English
