Product Description: WHI-P154 is a potent EGFR inhibitor, and also modestly blocks JAK3, with IC50s of 4 nM and 1.8 μM, respectively.
Applications: Cancer-Kinase/protease
Formula: C16H14BrN3O3
References: [1]Changelian PS, et al. The specificity of JAK3 kinase inhibitors. Blood. 2008 Feb 15;111(4):2155-7. Epub 2007 Dec 19./[2]Zhang H, et al. WHI-P154 enhances the chemotherapeutic effect of anticancer agents in ABCG2-overexpressing cells. Cancer Sci. 2014 Aug;105(8):1071-8.
CAS Number: 211555-04-3
Molecular Weight: 376.20
Compound Purity: 99.39
Research Area: Cancer
Solubility: DMSO : 50 mg/mL (ultrasonic)
Target: Apoptosis;EGFR;JAK