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CAS Number: 19545-26-7
Description: Potent and selective inhibitor of phosphatidyl-inositol 3-kinase. Active in purified preparations and cytosolic fractions(IC50 = 5nM) and is highly cell permeable. Covalently binds to PI 3-kinase and is selective, inhibiting other kinases such as PI 4-kinase and myosin light chain kinase at concentrations 100-fold higher than that required for inhibition of PI 3-kinase.
Format: White to off-white solid.
Purity: ≥99%
Storage Stability: Store at or below -20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.
Biosafety Level: Not applicable (BSL-1)
References: 1. Wymann, M.P. et al.; (1996). Mol. Cell. Biol. 16, 1722.
2. M. Ui, et al. (1995). TIBS 20, 303.
3. Arcaro, A. and Wyman, M.P. (1993). Biochem. J. 296, 297.
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