Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 3-hydroxy-benzoic acid, (3-fluoro-1,2-phenylene)ester
Purity: ≥98%
Formula Markup: C20H13FO6
Formula Weight: 368.3
CAS Number: 1223397-11-2
Notes: WZB117 is an irreversible inhibitor of glucose transporter 1 (Glut1) that blocks glucose transport in diverse cancer cells (IC50 = ~0.6 µM), reducing extracellular lactate and intracellular ATP levels.{32239} It inhibits cancer cell proliferation (IC50s = 5-10 µM), resulting in cell cycle arrest, senescence, and necrosis or apoptosis.{32239,32241} These effects are enhanced by the anticancer drugs cisplatin (Item No. 13119) and paclitaxel (Item No. 10461). WZB117, given intraperitoneally at 10 mg/kg, significantly reduces tumor size in mice, with only small reductions in body weight and leukocyte count.{32239} WZB117 also inhibits the self-renewal and tumor-initiating capacity of cancer stem cells, blocking tumor initiation after implantation of cancer stem cells in mice.{32240}
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