Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 4-[[3-[(3-methylphenyl)methoxy]phenyl]methylene]-1-phenyl-3,5-pyrazolidinedione
Purity: ≥98%
Formula Markup: C24H20N2O3
Formula Weight: 384.42728
CAS Number: 429653-73-6
Notes: An inhibitor of the Rho GEF 12-RhoA protein-protein interaction; binds to the DH-PH domain of Rho GEF 12 in a cell-free assay (Kd = 76 nM); inhibits serum-induced phosphorylation of MLC and FAK, a marker of RhoA activity, in NIH3T3 cells at 10 and 30 µM; inhibits cell growth, migration, invasion, and mammosphere formation in MCF-7 breast cancer cells from 5-30 µM