Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 2-(4-hydroxyphenyl)-1-(1,3,4,9-tetrahydro-2H-pyrido[3,4-b]indol-2-yl)-ethanone
Purity: ≥98%
Formula Markup: C19H18N2O2
Formula Weight: 306.4
CAS Number: 1373764-75-0
Notes: An anticancer agent; reduces TGF-β-induced transcriptional activity by 72.4% in a reporter assay using HaCaT cells at 1 µM; inhibits the proliferation of PC-9, H1299, and A549 cells (IC50s = 5.87, 8.07, and 7.9 µM, respectively); decreases migration of H1299 cells in a wound healing assay at 0.1, 0.5, or 1 µM; inhibits actin polymerization in HT-29 cells at 50 µM; inhibits fibronectin-induced increases in the levels of MMP-2, MMP-9, and phosphorylated FAK, PI3K, and ERK in CT26 cells at 50 µM; decreases tumor volume without reducing body weight in an A549 mouse xenograft model at 5 mg/kg per day; reduces tumor growth and the number of hepatic metastases in a CT26-luc colon cancer mouse xenograft model with hepatic metastases at 50 mg/kg per day
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