Product Description: YH239-EE, ethyl ester of the free carboxylic acid compound YH239, is a potent p53-MDM2 antagonizing and apoptosis-inducing agent.IC50 value:Target: MDM2/p53YH239-EE inhibits the growth of OCI-AML-3 cells with wild type p53 by inhibiting the p53-MDM2 interaction. YH239-EE induces cell cycle arrest and causes potent cell apoptosis via activation of p53 and downstream targets in four AML cells (OCI-AML-3 and MOLM-13 with wt p53, NB4 with p53 mutation, and HL60 with p53 deletion).
Applications: Cancer-programmed cell death
Formula: C25H27Cl2N3O4
References: [1]Huang Y, et al. Discovery of highly potent p53-MDM2 antagonists and structural basis for anti-acute myeloid leukemia activities. ACS Chem Biol. 2014 Mar 21;9(3):802-11.
CAS Number: 1364488-67-4
Molecular Weight: 504.41
Compound Purity: 98.28
Research Area: Cancer
Solubility: DMSO : ≥ 55 mg/mL
Target: Apoptosis;E1/E2/E3 Enzyme;MDM-2/p53
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