Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: N-ethyl-1,6-dihydro-1,2-dimethyl-6-(methylimino)-N-phenyl-4-pyrimidinamine, monohydrochloride
Purity: ≥98%
Formula Markup: C15H21N4 / Cl
Formula Weight: 292.8
CAS Number: 133059-99-1
Notes: Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated (HCN) channels contribute to native pacemaker currents in heart and neurons and modulate cardiac and neuronal excitability.{28047} Certain HCN channels also accentuate neuropathic pain.{28043} ZD 7288 is a potent blocker of HCN channels that inhibits HCN4 more potently than HCN1 (IC50s = 32 and 158 nM, respectively).{28045} Through its effects on HCN channels, ZD 7288 modulates the sinoatrial node and slows heart rate.{28049,28044} In addition, ZD 7288 reduces neuropathic pain in several animal models.{28046,28048}
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