Product Description: Zenidolol (ICI-118551) is a selective β2 adrenergic receptor antagonist. Zenidolol inhibits β2-, β1- and β3-adrenergic receptor with Ki values of 0.7, 49.5 and 611 nM, respectively. Zenidolol can be used as an ocular hypotensive agent used for ophthalmic disease research[1].
Applications: COVID-19-immunoregulation
Formula: C17H27NO2
Citations: bioRxiv. 2024 Feb 19./J Endocrinol. 2023 Feb 16;256(3):e220335./Nat Commun. 2023 May 2;14(1):2523./Adv Sci (Weinh). 2024 Sep 4:e2402393./Biochem Biophys Res Commun. 2024 Feb 15, 149689./Biomed Pharmacother. 2023 Mar 15;161:114523./bioRxiv. 2020 Jan./BMC Ophthalmol. 2021 Dec 5;21(1):419./BMC Cancer. 2019 Nov 26;19(1):1142./Br J Pharmacol. 2020 Jan;177(2):282-297. /Cancer Discov. 2024 Aug 13./Commun Biol. 2021 Dec 3;4(1):1359./Commun Biol. 2022 Apr 8;5(1):339./Diabetes. 2022 May 1;71(5):921-933./Environ Toxicol. 2023 Dec 2./Eur J Pharmacol. 2022 Jun 20;175110./Int Dent J. 2024 Jul 22:S0020-6539(24)00166-7./Int J Biol Sci. 2023 Apr 2,19./J Exp Clin Cancer Res. 2019 Apr 25;38(1):174. /J Exp Med. 2023 Nov 6;220(11):e20230577./J Nutr Biochem. 2018 May 1;58:110-118./J Oral Maxillofac Surg. 2020 Oct;78(10):1871.e1-1871.e23./J Pharm Anal. 2024 Jan 4./Mol Oncol. 2022 May 20./Nat Commun. 2020 Sep 25;11(1):4857./Nat Commun. 2021 Nov 26;12(1):6937./Nat Commun. 2024 Nov 28;15(1):10361./Neuroscience. 2019 Mar 1;401:59-72. /Oncol Rep. 2016 Sep;36(3):1576-84. /Pflugers Arch. 2021 Sep 26./Research Square Preprint. 2020 Oct./Research Square Preprint. 2021 Feb./Research Square Preprint. 2021 Nov./Research Square Preprint. 2021 Sep./Research Square Preprint. 2022 Mar./Sci Adv. 2024 Jul 19;10(29):eadp5239.
References: [1]Hoffmann C, et al. Comparative pharmacology of human beta-adrenergic receptor subtypes--characterization of stably transfected receptors in CHO cells. Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):151-9.
CAS Number: 72795-26-7
Molecular Weight: 277.40
Compound Purity: 99.60
Research Area: Inflammation/Immunology
Solubility: DMSO : 100 mg/mL (ultrasonic;warming;heat to 60°C)
Target: Adrenergic Receptor
Deutsch
English
