ZFYVE28 (Zinc Finger FYVE-type containing 28)(LST2/2426), CF740 conjugate, 0.1mg/mL

ZFYVE28 (Zinc Finger FYVE-type containing 28)(LST2/2426), CF740 conjugate, 0.1mg/mL
Artikelnummer
BTMBNC742426-500
Verpackungseinheit
500 uL
Hersteller
Biotium

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Description: ZFYVE28 belongs to the lst-2 family. It contains 1 FYVE-type zinc finger. The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not mono-ubiquitinated at Lys-87. Mono-ubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. ZFYVE28 is a negative regulator of epidermal growth factor receptor (EGFR) signaling. It acts by promoting EGFR degradation in endosomes when not mono-ubiquitinated. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Product Origin: Animal - Mus musculus (mouse), Bos taurus (bovine)

Conjugate: CF740

Concentration: 0.1 mg/mL

Storage buffer: PBS, 0.1% rBSA, 0.05% azide

Clone: LST2/2426

Immunogen: Recombinant full-length human ZFYVE28 protein

Antibody Reactivity: ZFYVE28

Entrez Gene ID: 57732

Z-Antibody Applications: IHC, FFPE (verified)

Verified AB Applications: IHC (FFPE) (verified)
Mehr Informationen
Artikelnummer BTMBNC742426-500
Hersteller Biotium
Hersteller Artikelnummer BNC742426-500
Verpackungseinheit 500 uL
Mengeneinheit STK
Reaktivität Human
Klonalität Monoclonal
Methode Immunohistochemistry
Isotyp IgG2a kappa
Wirt Mouse
Konjugat Conjugated, CF740
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