Zileuton-d4, CAS 1189878-76-9

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: N-(1-benzo[b]thien-2-ylethyl-d4)-N-hydroxy-urea

Purity: ≥99% deuterated forms (d1-d4)

Formula Markup: C11H8D4N2O2S

Formula Weight: 240.3155

CAS Number: 1189878-76-9

Notes: Zileuton-d4 is intended for use as an internal standard for the quantification of zileuton (Item No. 10006967) by GC- or LC-MS. Zileuton is a reversible 5-lipoxygenase (5-LO) inhibitor.{1367} It inhibits 5-LO activity in rat basophilic leukemia-1 (RBL-1) cell supernatant with an IC50 value of 0.5 µM. Zileuton inhibits leukotriene B4 (LTB4; Item No. 20110) production induced by the calcium ionophore A23187 (Item No. 11016) in purified human peripheral blood polymorphonuclear leukocytes (PMNLs; IC50 = 0.6 µM). Zileuton (10 mg/kg, p.o.) prevents antigen challenge-induced increases in specific lung resistance in a sheep model of asthma at 4 to 8 hours post-challenge following administration 2 hours pre-challenge.{42699} Formulations containing zileuton have been used in the prophylaxis and chronic treatment of asthma.

• Artikelnummer: CAY26761-1
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 26761-1
• Verpackungseinheit: 1 mg
• Mengeneinheit: STK
• Methode: GC-MS, LC-MS, Isotopenmarkierung