Zoniporide (hydrochloride), CAS 241800-97-5

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-(aminoiminomethyl)-5-cyclopropyl-1-(5-quinolinyl)-1H-pyrazole-4-carboxamide, monohydrochloride

Purity: ≥98%

Formula Markup: C17H16N6O / HCl

Formula Weight: 356.8

CAS Number: 241800-97-5

Notes: The sodium-hydrogen exchanger isoform-1 (NHE-1) is the most predominant isoform of the Na+/H+ exchanger and is expressed in the heart where it contributes to cardiomyocyte pH homeostasis.{22706} It plays an important role in the myocardial response to ischemia-reperfusion. Zoniporide inhibits human NHE-1 with an IC50 value of 14 nM, displaying greater than 150-fold selectivity over other NHE isoforms.{25880} It has been shown to reduce infarct size in a rabbit myocardial ischemia-reperfusion model without adversely affecting hemodynamics or cardiac function.{22706} In isolated heart, zoniporide reduced infarct size with an EC50 value of 0.25 nM.{25880}

• Artikelnummer: CAY16004-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 16004-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK