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Anti-Mouse CD4 In Vivo Antibody - Ultra Low Endotoxin (OKT-4)

Anti-Mouse CD4 In Vivo Antibody - Ultra Low Endotoxin (OKT-4)
436,71 €
Artikelnummer: ICH1166UL-5MG

Verfügbarkeit: Lieferzeit auf Anfrage

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Anti-Mouse CD4 In Vivo Antibody - Ultra Low Endotoxin (OKT-4), Host: Mouse, IgG2b

Details

Clone: OKT-4.
Target: CD4.
Specificity: Clone OKT4 recognizes Human CD4. This clone recognizes a different epitope than the RPA-T4 monoclonal antibody, and these antibodies do not interfere with each other.
Immunogen: Human peripheral T cells.
Purification Method: This monoclonal antibody was purified using multi-step affinity chromatography methods such as Protein A or G depending on the species and isotype.
Antigen Distribution: CD4 is expressed on most thymocytes, a subset of T cells, and monocytes/macrophages, and may be detected in thymus, lymph nodes, tonsils, and spleen, and also in specific regions of the brain, gut, and other non-lymphoid tissues.

Background: Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells, plays a role in differentiation/activation, cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.(Microbial infection) Primary receptor for human immunodeficiency virus-1 (HIV-1). Down-regulated by HIV-1 Vpu. Acts as a receptor for Human Herpes virus 7/HHV-7.

Purity: >98% by SDS-PAGE and HPLC.
Endotoxin: ≤ 0.75 EU/mg as determined by the LAL method.

Zusatzinformation

Artikelnummer ICH1166UL-5MG
Hersteller Ichorbio
Herstellernummer ICH1166UL-5MG
Verpackungseinheit 5 mg
Mengeneinheit FL
Reaktivität Human
Klonalität Monoclonal
Wirt / Host Mouse
Methode ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry (frozen), Immunoprecipitation, Neutralization, Western Blotting
Isotype IgG2b
Gene ID Keine Herstellerangabe
Datenblatt Download
MSDS Auf Anfrage