Chronic bronchitis is marked by long-term cough and excess mucous. Emphysema leads to the destruction of the lungs over time. Most people with COPD have a combination of both conditions. Usually COPD is associated with bronchial epithelium changes.Cryopreserved Lonza's Diseased Bronchial Epithelial cells test negative for mycoplasma, bacteria, yeast, and fungi. HIV-1, hepatitis B and hepatitis C are not detected for all donors and/or cell lots. A Certificate of Analysis is provided for each cell lot purchased.Our catalog number 00195275S are suitable for air-liquid interface studies and are guaranteed to promote full differentiation of the airway epithelium expressed by the formation of a polarized epithelium with good barrier function (transepithelial resistance), secretory phenotype (mucin secretion) and ciliogenesis. Differentiation usually will occur by day 22 in culture.