Chronic bronchitis is marked by long-term cough and excess mucous. Emphysema leads to the destruction of the lungs over time. Most people with COPD have a combination of both conditions. Usually COPD is associated with bronchial epithelium changes.
Lonza's Human Small Airway Epithelial Cells (SAEC) are isolated from normal human lung tissue from COPD donors the distal portion of the lung in the 1mm bronchiole area.
Cryopreserved CloneticsTM SAECs are guaranteed through 15 population doublings and stain positive for cytokeratin 19. SAECs labeled CC-2547S are suitable for air-liquid interface studies and areguaranteed for differentiation marked by cilia formation, mucin production, and TEER levels. All cells testnegative for mycoplasma, bacteria, yeast, and fungi. HIV-1, hepatitis B andhepatitis C are not detected for all donors and/or cell lots. A Certificate ofAnalysis is provided for each cell lot purchased.