Clone Name: HL2588
Light Chain: Kappa
Application Note: ICC/IF: 1:100-1:1000. *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications.
Calculated MW: 34
Form: Liquid
Buffer (with preservative): PBS, no Preservative.
Concentration: 1 mg/ml (Please refer to the vial label for the specific concentration.)
Background: This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8% of humans with the autoimmune disease scleroderma recognize fibrillarin. [provided by RefSeq, Jul 2008]
Uniprot ID: P22087
Antigen Species: Human
Immunogen: Recombinant fragment of human fibrillarin.
Purification: Affinity purified by Protein A.
Conjugation: Unconjugated
Full Name: fibrillarin
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