(S)-5-hydroxy-6-methoxy Duloxetine (maleate)

Formulation: A solid

Formal Name: 2-methoxy-5-[(1S)-3-(methylamino)-1-(2-thienyl)propoxy]-1-naphthalenol, maleate

Purity: ≥95%

Formula Markup: C19H21NO3S • C4H4O4

Formula Weight: 459,5

Shelf life (days): 1460

Notes: (S)-5-hydroxy-6-methoxy Duloxetine is an active metabolite of the serotonin (5-HT) and norepinephrine reuptake inhibitor (S)-duloxetine (Item No. 14317).{48296,47342} It is formed from (S)-duloxetine via a 5- or 6-hydroxy duloxetine intermediate, which is formed by the cytochrome P450 (CYP) isoforms CYP1A2 and CYP2D6, and a catechol duloxetine intermediate.{47342} (S)-5-hydroxy-6-methoxy Duloxetine inhibits the 5-HT transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) in lipid membranes (Kis = 266, 920, and 2,814 nM, respectively, for the human transporters).{48296}

• Artikelnummer: CAY39381-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 39381-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK