Shelf life (days): 1460.0
Formulation: A crystalline solid
Formal Name: 6-(acetyloxy)-benzoic-2,3,4,5-d4 acid
Purity: ≥95%
Formula Markup: C9H4D4O4
Formula Weight: 184.2
CAS Number: 97781-16-3
Notes: Aspirin-d4 is intended for use as an internal standard for the quantification of aspirin (Item No. 70260) by GC- or LC-MS. Aspirin is a non-steroidal anti-inflammatory drug (NSAID) and a covalent inhibitor of COX-1 and COX-2 (IC50s = 4.45 and 13.88 µM, respectively, for the human enzymes).{32442} It is also an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50 = 750 µM for the ovine enzyme).{1364} Aspirin (6 µg/ml) inhibits epinephrine- and ADP-induced platelet aggregation.{46641} In vivo, aspirin (30 mg/kg) reduces infarct volume and microglial infiltration in a rat model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).{52662} It decreases macrophage infiltration into, increases the number of smooth muscle cells and levels of collagen in, and reduces the area of, atherosclerotic lesions in LDL receptor-deficient mice fed a high-fat diet when administered in the drinking water at 30 mg/L.{15290} Formulations containing aspirin have been used in the treatment of pain, fever, and in stroke prevention.
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