BRD0639, CAS 2760881-74-9

Shelf life (days): 1460.0

Formulation: A solid

Formal Name: (aS)-4-chloro-a-methyl-N-[4-methyl-3-[[[2-(2-pyridinyl)ethyl]amino]sulfonyl]phenyl]-6-oxo-1(6H)-pyridazineacetamide

Purity: ≥98%

Formula Markup: C21H22ClN5O4S

Formula Weight: 475.94938

CAS Number: 2760881-74-9

Notes: BRD0639 is an inhibitor of the protein-peptide interaction between protein arginine methyltransferase 5 (PRMT5) and PRMT5 binding motif (PBM; IC50 = 13.8 µM), a conserved peptide motif contained in PRMT5 substrate adaptor proteins (SAPs) that mediates SAP binding to PRMT5.{62562} It induces the formation of PRMT5 adducts in cells (EC50 = 3 µM) and disrupts complex formation between PRMT5 and the SAP RIO kinase 1 (RIOK1) in permeabilized cells.

• Artikelnummer: CAY35625-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 35625-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK
• Methode: Reinstoffe