Clone Name: HL2742
Light Chain: Kappa
Specificity/Sensitivity: This antibody recognizes p38 MAPK when dually phosphorylated at Tyr180 and Tyr182. It may show minor cross-reactivity with p38 MAPK phosphorylated at Tyr182 but does not cross-react with p38 MAPK phosphorylated at Tyr180.
Form: Liquid
Buffer (with preservative): PBS, no Preservative.
Concentration: batch dependent (Please refer to the vial label for the specific concentration.)
Background: The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Uniprot ID: Q16539
Antigen Species: Human
Immunogen: Carrier-protein conjugated synthetic peptide surrounding phospho Thr180/Tyr182 of human p38 MAPK. The exact sequence is proprietary.
Purification: Affinity purified by Protein A.
Conjugation: Unconjugated
Full Name: mitogen-activated protein kinase 14
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