PLX7904, CAS 1393465-84-3

Product Description: PLX7904 is a potent and selective BRAF inhibitor, with IC50 of appr 5 nM against BRAFV600E in mutant RAS expressing cells.

Applications: Cancer-Kinase/protease

Formula: C24H22F2N6O3S

References: [1]Zhang C, et al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature. 2015 Oct 22;526(7574):583-586./[2]Basile KJ, et al. Inhibition of mutant BRAF splice variant signaling by next-generation, selective RAF inhibitors. Pigment Cell Melanoma Res. 2014 May;27(3):479-84/[3]Le K, et al. Selective RAF inhibitor impairs ERK1/2 phosphorylation and growth in mutant NRAS, vemurafenib-resistant melanoma cells. Pigment Cell Melanoma Res. 2013 Jul;26(4):509-17

CAS Number: 1393465-84-3

Molecular Weight: 512.53

Compound Purity: 98.94

Research Area: Cancer

Solubility: DMSO : ≥ 30 mg/mL

Target: Raf

• Artikelnummer: MEXHY-18997-10.1
• Hersteller: MedChemExpress
• Hersteller Artikelnummer: HY-18997-10.1
• Verpackungseinheit: 10 mM/1 ml
• Mengeneinheit: STK