SB 225002, CAS 182498-32-4

Shelf life (days): 1460.0

Formulation: A crystalline solid

Formal Name: N-(2-bromophenyl)-N'-(2-hydroxy-4-nitrophenyl)-urea

Purity: ≥95%

Formula Markup: C13H10BrN3O4

Formula Weight: 352.1

CAS Number: 182498-32-4

Notes: CXCR2 (IL-8RB) is a seven-transmembrane G protein-coupled receptor whose physiological ligands include IL-8 (CXCL8) and growth related oncogene α (Gro-α; CXCL1). IL-8 and Gro-α are pro-inflammatory CXC chemokines that act as chemoattractants, especially for neutrophils, and promote angiogenesis. SB 225002 is a selective non-peptide inhibitor of CXCR2, inhibiting IL-8 binding to CXCR2 with an IC50 value of 22 nM.{17249} SB225002 inhibits neutrophil chemotaxis in response to IL-8 in vitro (IC50 = 20 nM) and blocks neutrophil margination induced by IL-8 in vivo (IC50 = 30 nM).{17249} Similarly, SB 225002 reduces neutrophil influx, the production of inflammatory mediators, and tissue damage in TNBS-induced colitis in mice.{17248}

• Artikelnummer: CAY13336-5
• Hersteller: Cayman Chemical
• Hersteller Artikelnummer: 13336-5
• Verpackungseinheit: 5 mg
• Mengeneinheit: STK