TRKB Kinase Assay Kit

Products from BPS Bioscience require a minimum order value above 400€

Applications: Study enzyme kinetics and screen small molecular inhibitors for drug discovery and high throughput (HTS) applications.

Background: Tropomyosin receptor kinase B (TRKB) is a high-affinity catalytic receptor for neurotrophins and is part of a large family of tyrosine kinases. Once activated by specific neurotrophins, such as brain derived neurotrophic factor (BDNF), TRKB mediates neuronal differentiation and survival. TRKB and BDNF have been associated with the pathology and progression of Alzheimer's disease and other neurodegenerative disorders. More recently as a member of TRK proto-oncogene family, TRKB inhibitors have become of interest as a possible cancer therapy. 

Contraindications: The final concentration of DMSO in the assay should not exceed 1%. 

Description: The TRKB Kinase Assay Kit is designed to measure TRKB kinase activity for screening and profiling applications using ADP-Glo® as a detection reagent. 

Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed. 

Supplied As: The TRKB Kinase Assay Kit comes in a convenient 96-well format, with enough purified recombinant TRKB kinase, kinase substrate, ATP and kinase assay buffer for 100 enzyme reactions.

Uniprot: Q16620

Warnings: Avoid freeze/thaw cycles. 

Biosafety Level: Not applicable (BSL-1)

• Artikelnummer: BPS78591
• Hersteller: BPS Bioscience
• Hersteller Artikelnummer: 78591
• Green Labware: Nein
• Verpackungseinheit: 96 rxns.
• Mengeneinheit: PAK