Product Description: WYE-132 (WYE-125132) is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor (IC50: 0.19±0.07 nM; >5,000-fold selective versus PI3Ks). WYE-132 (WYE-125132) inhibits mTORC1 and mTORC2.
Applications: Cancer-Kinase/protease
Formula: C27H33N7O4
References: [1]Yu K, et al. Beyond rapalog therapy: preclinical pharmacology and antitumor activity of WYE-125132, an ATP-competitive and specific inhibitor of mTORC1 and mTORC2.Cancer Res. 2010 Jan 15;70(2):621-631.
CAS Number: 1144068-46-1
Molecular Weight: 519.60
Compound Purity: 99.90
Research Area: Cancer
Solubility: DMSO : 25 mg/mL (ultrasonic)
Target: Apoptosis;mTOR