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Cathepsin K Inhibitor Screening Assay Kit
Cathepsin K Inhibitor Screening Assay Kit
Artikelnummer
BPS78810-1
Verpackungseinheit
96 reactions
Hersteller
BPS Bioscience
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Products from BPS Bioscience require a minimum order value above 400€
Applications: Screen small molecule inhibitors in high throughput screening (HTS) applications.
Background: Cathepsin K is a potent protease that belongs to the lysosomal cysteine protease family. It mediates bone resorption and is an attractive target for anti-osteoporosis drug development. The protease has also been associated with skeletal homeostasis as mutation in the gene encoding cathepsin K is linked to a rare autosomal recessive disorder, pycnodysostosis, which is characterized by abnormal bone density and decreased bone turnover. Further, cathepsin K has been implicated in diseases of the central nervous system (CNS), cardiovascular system, and the respiratory system. Studying cathepsin K can lead to a better understanding of its role in disease beyond the musculoskeletal system.
Description: The Cathepsin K Inhibitor Screening Assay Kit is designed to measure the protease activity of Cathepsin K for screening and profiling applications. The Cathepsin K assay kit comes in a convenient 96-well or 384-well format, with enough purified Cathepsin K, its substrate, and Cathepsin Buffer for 96 or 384 reactions. This kit includes the inhibitor E-64 as control.The substrate is an internally quenched flourogenic substrate.Proteolysis releases the highly flourescent Mca from the quencher. Flourescence intensity increases proportionally to the activity og the protease.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
Supplied As: The Cathepsin K assay kit comes in a 96-well format, with purified Cathepsin K, its fluorogenic substrate, and Cathepsin buffer for 100 enzyme reactions.
Uniprot: P43235
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
Applications: Screen small molecule inhibitors in high throughput screening (HTS) applications.
Background: Cathepsin K is a potent protease that belongs to the lysosomal cysteine protease family. It mediates bone resorption and is an attractive target for anti-osteoporosis drug development. The protease has also been associated with skeletal homeostasis as mutation in the gene encoding cathepsin K is linked to a rare autosomal recessive disorder, pycnodysostosis, which is characterized by abnormal bone density and decreased bone turnover. Further, cathepsin K has been implicated in diseases of the central nervous system (CNS), cardiovascular system, and the respiratory system. Studying cathepsin K can lead to a better understanding of its role in disease beyond the musculoskeletal system.
Description: The Cathepsin K Inhibitor Screening Assay Kit is designed to measure the protease activity of Cathepsin K for screening and profiling applications. The Cathepsin K assay kit comes in a convenient 96-well or 384-well format, with enough purified Cathepsin K, its substrate, and Cathepsin Buffer for 96 or 384 reactions. This kit includes the inhibitor E-64 as control.The substrate is an internally quenched flourogenic substrate.Proteolysis releases the highly flourescent Mca from the quencher. Flourescence intensity increases proportionally to the activity og the protease.
Storage Stability: This assay kit will perform optimally for up to 6 months from date of receipt when the materials are stored as directed.
Supplied As: The Cathepsin K assay kit comes in a 96-well format, with purified Cathepsin K, its fluorogenic substrate, and Cathepsin buffer for 100 enzyme reactions.
Uniprot: P43235
Warnings: Avoid freeze/thaw cycles
Biosafety Level: Not applicable (BSL-1)
| Artikelnummer | BPS78810-1 |
|---|---|
| Hersteller | BPS Bioscience |
| Hersteller Artikelnummer | 78810-1 |
| Verpackungseinheit | 96 reactions |
| Mengeneinheit | PAK |
| Produktinformation (PDF) | Download |
| MSDS (PDF) |
|
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