5-Hydroxydiclofenac, CAS 69002-84-2

Product Description: 5-Hydroxydiclofenac is a major metabolite of Diclofenac (HY-15036). 5-Hydroxydiclofenac is formed by the cytochrome P450 (CYP) isoforms CYP3A4, CYP2C189, CYP2C19, and CYP2C8. 5-Hydroxydiclofenac shows apoptotic effects in hepatocytes[1].

Formula: C14H11Cl2NO3

References: [1]A Mancy, et al. Diclofenac and its derivatives as tools for studying human cytochromes P450 active sites: particular efficiency and regioselectivity of P450 2Cs. Biochemistry. 1999 Oct 26;38(43):14264-70. /[2]M José Gómez-Lechón, et al. Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS. Biochem Pharmacol. 2003 Dec 1;66(11):2155-67.

CAS Number: 69002-84-2

Molecular Weight: 312.15

Research Area: Cancer

Target: Apoptosis;Drug Metabolite

• SKU: MEXHY-124542-5
• Manufacturer: MedChemExpress
• Manufacturer SKU: HY-124542-5
• Package Unit: 5 mg
• Quantity Unit: STK