Gene Editing

Gene Editing

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) are segments of short, regularly placed palindromic nucleotide repetitions. CAS (CRISPR-Associated Protein) is a CRISPR-associated nuclease enabling controlled DNA cleavage.

CRISPR/Cas9 systems allow for targeted gene editing. Briefly, aCRISPR/Cas9 complex binds to a specific DNA sequence, cuts it out and replaces the original sequence with a new sequence. Guide RNA (gRNA) helps to navigate the CRISPR/Cas9 complex in order to target only the specific sequence.

CRISPR/Cas9 represents a valuable tool in gene editing and becomes even more popular in therapy, especially of cancer and other disease involving genetic defects (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6315587/).

Picture: CRISPR/Cas9 induced DNA double-strand break.

Highlights:

  • Double nickase plasmids
  • CRISPR/dCas9 activation plasmids
  • CRISPR/dCas9 lentiviral activation particles
  • CRISPR/Cas9 plasmids
  • HDR plasmids
  • CRE vector
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  1. hspCas9 AAVS1 Safe Harbor Knock-in Donor (AAVS1-SA-puro-EF1-hspCas9), Complete Kit
    hspCas9 AAVS1 Safe Harbor Knock-in Donor (AAVS1-SA-puro-EF1-hspCas9), Complete Kit
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    Sku SBYCAS620A-KIT
    Manufact. SkuCAS620A-KIT
    Packaging Unit1 kit
  2. Purified Cas9 Protein (NLS-Cas9-NLS)
    Purified Cas9 Protein (NLS-Cas9-NLS)
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    Sku SBYCAS410A-1
    Manufact. SkuCAS410A-1
    Packaging Unit50 µg
  3. Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit
    Cas9 Protein and T7 gRNA SmartNuclease Synthesis Kit
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    Sku SBYCAS410A-KIT
    Manufact. SkuCAS410A-KIT
    Packaging Unit1 kit (10 rxn)
  4. EGFP-labeled Cas9 Protein (NLS-Cas9-EGFP)
    EGFP-labeled Cas9 Protein (NLS-Cas9-EGFP)
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    Sku SBYCAS420A-1
    Manufact. SkuCAS420A-1
    Packaging Unit50 µg
  5. Cas9-EGFP Protein and T7 gRNA SmartNuclease Synthesis Kit
    Cas9-EGFP Protein and T7 gRNA SmartNuclease Synthesis Kit
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    Sku SBYCAS420A-KIT
    Manufact. SkuCAS420A-KIT
    Packaging Unit1 kit (10 rxn)
  6. Transfection-ready Cas9 SmartNuclease mRNA (Eukaryotic version)
    Transfection-ready Cas9 SmartNuclease mRNA (Eukaryotic version)
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    Sku SBYCAS500A-1
    Manufact. SkuCAS500A-1
    Packaging Unit20 µg
  7. Transfection-ready Cas9 SmartNickase mRNA (Eukaryotic Nickase mutant version)
    Transfection-ready Cas9 SmartNickase mRNA (Eukaryotic Nickase mutant version)
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    Sku SBYCAS504A-1
    Manufact. SkuCAS504A-1
    Packaging Unit20 µg
  8. Linearized T7 gRNA SmartNuclease vector
    Linearized T7 gRNA SmartNuclease vector
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    Sku SBYCAS510A-1
    Manufact. SkuCAS510A-1
    Packaging Unit10 rxn
  9. T7 gRNA SmartNuclease Synthesis Kit (includes CAS510A-1 & T7 IVT synthesis reagents)
    T7 gRNA SmartNuclease Synthesis Kit (includes CAS510A-1 & T7 IVT synthesis reagents)
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    Sku SBYCAS510A-KIT
    Manufact. SkuCAS510A-KIT
    Packaging Unit1 Kit
  10. Extra T7 gRNA PCR primer mix (5 uM)
    Extra T7 gRNA PCR primer mix (5 uM)
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    Sku SBYCAS510A-PR
    Manufact. SkuCAS510A-PR
    Packaging Unit50 assays
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