Shelf life (days): 1460.0
Formulation: A solid
Formal Name: 3-((4R,7S,10S,13R,16S,19S,22R)-16-((1H-imidazol-5-yl)methyl)-7-((1H-indol-3-yl)methyl)-22-((R)-2-acetamido-5-guanidinopentanamido)-13-benzyl-4-carbamoyl-10-(3-guanidinopropyl)-6,9,12,15,18,21-hexaoxo-1,2-dithia-5,8,11,14,17,20-hexaazacyclotricosan-19-yl)propanoic acid, trifluorocetate salt
Amino Acids: Ac-rCEHfRWC-NH2
Purity: ≥98%
Formula Markup: C51H70N18O11S2 / XCF3COOH
Formula Weight: 1175.4
Notes: Ac-(D-Arg)-CEH-(D-Phe)-RWC-NH2 is a cyclic peptide and an agonist of melanocortin receptor 4 (MC4R).{69882} It induces cAMP release in HEK293 cells expressing human MC4R (EC50 = 0.28 nM). Ac-(D-Arg)-CEH-(D-Phe)-RWC-NH2 is selective for MC4R over MC1R, MC3R, and MC5R (Kis = 0.55, 16.78, 56.79, and >500 nM, respectively). It decreases food intake and body weight in a rat model of diet-induced obesity when administered at doses of 0.075 or 0.299 µmol/kg.
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