Shelf life (days): 1460.0
Formulation: A solid
Formal Name: a11-24-corticotropin, acetate
Amino Acids: KPVGKKRRPVKVYP-OH
Purity: ≥98%
Formula Markup: C77H134N24O16 / XC2H4O2
Formula Weight: 1652.0
Notes: Adrenocorticotropic hormone (ACTH) (11-24) is a peptide fragment of ACTH (Item No. 24257), a peptide hormone found in the brain that is involved in the biological stress response, and an antagonist of melanocortin receptor 2 (MC2R), also known as the ACTH receptor (IC50 = ~1 nM in HeLa cells expressing the mouse receptor).{45140,38619} It induces corticosterone and aldosterone production in isolated rat zona glomerulosa and zona fasciculata cells, respectively, with minimum effective concentrations of 4 and 3 µM, respectively.{67900} Unlike ACTH (4-11) (Item No. 27430), ACTH (11-24) does not induce differentiation of primary mouse melanocytes.{48426} In vivo, ACTH (11-24) (1.69 µg/animal, i.c.v.) inhibits ACTH-induced stretching, yawning, and penile erections in rats.{67901}
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