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Encompassing Amino Acids: 19-137
Application: Useful for binding studies.
Assay Conditions: Assay was done according to Activin A: Activin RIIB[Biotinylated] Inhibitor Screening Assay Kit (BPS Bioscience #82531) with various amounts of Activin RIIB.
Background: Activin A receptor type IIB, also known as ACVR2B, together as a complex with Activin A receptor type I (ACVRI), form a transmembrane receptor with serine/threonine kinase activity. Upon binding of activin, the kinase activity of the receptor is activated, SMAD2 (mothers against decapentaplegic homolog 2) and SMAD3 are phosphorylated, form a complex with SMAD4 and translocate to the nucleus, regulating gene expression. Activin A can be found in macrophages, dendritic cells, and neutrophils, playing a role in cell maturation and activation. It is involved in inflammation and autoimmune disorders, such as SLE (systemic lupus erythematosus), RA (rheumatoid arthritis), and atopic dermatitis. It is also involved in bone formation. The use of fusion protein blockers of the activin signaling pathways, that serve as sinks for activin A and other TGFβ (transforming growth factor beta) members, is being explored for the treatment of pulmonary hypertension, chemotherapy-induced anemia, and osteoporosis.
Description: Recombinant human Activin RIIB (receptor IIB), also known as ACVR2B, encompassing amino acids 19-137. At the C-terminal this construct contains a His-tag (10xHis) followed by an Avi-tag™. The recombinant protein was enzymatically biotinylated using the Avi-Tag™ and affinity purified.
Format: Aqueous buffer solution
Formulation: 8 mM phosphate, pH 7.4, 110 mM NaCl, 2.2 mM KCl, and 20% glycerol
Genbank: NM_00110634
Purity: ≥90%
Storage Stability: At least 6 months at –80°C.
Tags: His-Avi
Target: ACVR2B
Uniprot: Q13705
Warnings: Avoid freeze/thaw cycles.
Biosafety Level: Not applicable (BSL-1)
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