Target: Alpha Synuclein Aggregate Antibody
Conjugate: FITC
Product Type: Monoclonal
Clone Number: 2F11
Immunogen: Mouse alpha synuclein fibrils
Swiss-Prot: O55042
Purification: Protein G Purified
Storage Buffer: PBS pH 7.4, 50% glycerol, 0.09% sodium azide. *Storage buffer may change when conjugated
Concentration: 1mg/ml
Specificity: Binds a 3-dimensional fibrillar epitope including AA101-120, AA61-80
Cellular Localization: Cell Junction, Cytoplasm, Cytosol, Membrane, Nucleus, Synapse
Scientific Background: Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions; inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimer’s disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Covered by US patent family US11,098,108B2 (7).
References: 1. “Genetics Home Reference: SNCA”. US National Library of Medicine. (2013).2. Zhang L., et al. (2008) Brain Res. 1244: 40-52.3. Alim M.A., et al. (2002) J Biol Chem. 277(3): 2112-2117.4. Kokhan V.S., Afanasyeva M.A., Van'kin G. (2012) Behav. Brain. Res. 231(1): 226-230.5. Spillantini M.G., et al. (1997) Nature. 388(6645): 839-840.6. Mezey E., et al. (1998) Nat Med. 4(7): 755-757.7. Louwrier, A. US Patent family US11,098,108 B2
Field of Use: Not for use in humans. Not for use in diagnostics or therapeutics. For in vitro research use only.
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