Shelf life (days): 1460.0
Formulation: A solid
Formal Name: N-[3-fluoro-4-[(7-methoxy-4-quinolinyl)oxy]phenyl]-2,3-dihydro-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide
Purity: ≥98%
Formula Markup: C31H29FN4O5
Formula Weight: 556.6
CAS Number: 913376-84-8
Notes: AMG 1 is an inhibitor of c-Met and Ron (IC50s = 4 and 9 nM, respectively).{66830} It is selective for c-Met and Ron over seven tyrosine and serine/threonine kinases (IC50s = 160 to 1,900 nM). AMG 1 decreases the levels of phosphorylated MET, ERK1/2, and Akt in HT-29 colon and BxPC-3 pancreatic cancer cells, as well as reduces migration in a wound-healing assay using NIH3T3/TPR-Met fibroblasts, in a concentration-dependent manner. It reduces tumor volume in a U87 glioma mouse xenograft model when administered at a dose of 30 mg/kg twice per day. AMG 1 increases bone volume and bone regrowth area in a mouse model of calvarial defect when administered at a dose of 50 µg in an absorbable collagen sponge.{66831}
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